21 Renal Transplantation at the University of Pittsburgh : The Impact of FK 506
نویسندگان
چکیده
Ron Shapiro, Mark Jordan, Velma P. Scantlebury, Carlos Vivas, H. Albin Gritsch, Abdul S. Rao, Massimo Trucco, Adriana Zeevi, Anthony J. Demetris, Parmjeet Randhawa, Robert J. Corry, Francesca Egidi, Horacio Rilo, Camillo Ricordi, Patricia Carroll, Andreas Tzakis, Jerry McCauley, Demetrius Ellis, Nisan Gilboa, William Irish, Sandi Mitchell, John J. Fung, Thomas R. Hakala, Richard L. Simmons, and Thomas E. Starzl
منابع مشابه
A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients.
FK 506 (Tacrolimus-Prograf) was first used clinically in February 1989.1 and approved by the United States Food and Drug Administration in April 1994 as a new immunosuppressive agent for use after liver transplantation.2-4 It has also been utilized as the primary immunosuppressive agent after heart.5 lung,6 intestinal7 and islet8 transplantation. In renal transplantation, it has been studied ex...
متن کاملIntra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm
Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...
متن کاملPharmacokinetics of FK 506: preclinical and clinical studies.
FK 506 is a macrolide with potent immunosuppressive effects. Its immunosuppressive property has been documented in both in vitro! lymphocyte proliferation studies and in vivo studies. FK 506 treatment significantly prolongs graft survival in rats receiving heterotopic heart transplants. dogs receiving kidneys or livers. and baboons receiving kidney transplants.2 Currently, FK 506 is undergoing ...
متن کاملFK 506 in the management of nephrotic syndrome after renal transplantation.
N EPHROTIC syndrome developing after renal trans-plantation has many etiologies. Recurrent focal scle-rosing glomerulonephritis is' ane of the leading causes.! Other etiologies include: (1) transplant glomerulopathy; (2) chronic rejection; (3) de novo membranous glomerulone-phritis (ON); and (4) other recurrent glomerulonephropa-thies (membranoproliferative glomerulonephritis [MPGN] , systemic ...
متن کاملConversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications.
WITH the use of Cy A for clinical liver transplantation, I-year survival rates have approached 70%. Nevertheless, allograft rejection continues to be the most common cause of retransplantation and death. Clinical rejection occurs in 70% ofliver allograft recipients on CyA and steroid therapy. 1 In addition, nephrotoxicity is the principal and dose-limiting side effect of Cy A. Chronic renal dam...
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